Skip to content

1 Min Read Time


Improving the Production of Pegylated Pharmaceuticals

Background / Requirement

An international Biopharmaceutical company was looking to effectively wet and disperse Activated PEG into WFI water in support of the development of a PEGylated pharmaceutical. PEGylation, is a process of attaching the strands of the polymer PEG to molecules most typically peptides, proteins, and antibody fragments, that can help to meet the challenges of improving the safety and efficiency of many therapeutics. PEGylation, by increasing the molecular weight of a molecule, can impart several significant pharmacological advantages over the unmodified form, such as:

  • Improved drug solubility
  • Reduced dosage frequency, without diminished efficacy with potentially reduced toxicity
  • Extended circulating life
  • Increased drug stability
  • Enhanced protection from proteolytic degradation

The company was looking for a way to more rapidly add and hydrate this material, in a repeatable manner, without excessive aeration. Using in-tank dispersing mixers, the hydrophilic PEG has a strong tendency to clump, float, and build up on the vessel wall. In addition, batch-to-batch product variation was a concern.

Quadro's Approach

The Quadro Ytron® ZC Powder Disperser is uniquely engineered to incorporate and disperse extremely difficult-to-wet ingredients into a liquid stream in a single-pass. The advanced design of the ZC Disperser’s rotor/stator provides for intense shearing of the powders prior to hydration, to produce homogeneous dispersions that are completely free of lumps and “fish-eyes”. A near-perfect vacuum permits concentrations up to 35% by weight to be generated with minimal air entrainment. Because the powder is completely hydrated, yield is maximized and over-processing and wastage are eliminated compared to other in-line high shear and in-tank technologies. The ZC will typically reduce batch times by 90% and also result in average powder savings of 5 – 10%.


Following trials at Quadro Engineering and the companies' R&D facility, the company purchased an integrated powder wetting & dispersing module, consisting of:

  • Quadro Ytron® ZC powder disperser, 316SS wetted parts, .48 RA Electropolished
  • Integrated single-use, plastic bag, powder delivery system with full recovery wash port with an integrated feed pump, flowmeter, and flow control valves
  • Touch screen User interface with recipe control
  • PLC automation for start-up and shutdown sequencing of the pump, disperser, and valve components, flow control and totalizing, including bag rinse toward the end of powder addition cycle.

To learn more about Quadro Liquids High Shear Mixer Equipment please contact our team.


Posted by Matt Baumber


Blog articles direct to your inbox



Contact us

Request a call back or email response

For more information, please contact our team via the form below and a representative will contact you to answer any questions. Phone inquiries can also be made +1-519-884-9660.

Quadro Liquids

In nearly 20 years of delivering the most efficient high shear mixing and processing solutions to our customers worldwide. Quadro® Liquids technology has never allowed conventional thinking to get in the way. 

Our Range of High Shear Mixing Equipment